The Science

Behind the Formula

Patent-Pending Formula

U.S. Patent Application Filed—April 2024

Trimsulin Control is built on a patent-pending nutraceutical composition-a proprietary combination of plant-based ingredients selected to work together across multiple metabolic pathways involved in appetite regulation, blood sugar balance, and weight management.

Formulated by

Richard Clark Kaufman, PhD

Dr. Kaufman is an award-winning researcher and product formulator with over two decades of experience in nutraceutical and botanical science. As Chief Science Officer of FirstFitness Nutrition, he led the development of Trimsulin Control's patent-pending formula.

  • 3 international patents in nutraceutical and delivery-system science
  • Over 150 commercial products formulated across health and wellness
  • Recipient, 2018 Frost & Sullivan Nanoencapsulation Technology Innovation Award
  • Author, The Age Reduction System
Chief Science Officer,
FirstFitness Nutrition
Richard Clark Kaufman in a lab coat

How It Works

Natural GLP-1

Support

GLP-1 is a hormone your gut produces naturally after eating-it signals fullness, slows digestion, and helps regulate blood sugar.

Ingredients like Allulose, Inulin, and Berberine are documented natural GLP-1 secretagogues, supporting your body's own GLP-1 production with every dose.*‡

DPP-4 Enzyme

Support

DPP-4 is an enzyme that rapidly breaks down GLP-1 before it can do its job.

Berberine, Quercetin, and Mulberry Leaf Extract act as natural DPP-4 inhibitors, helping keep active GLP-1 elevated longer after each dose.*‡

Insulin Sensitivity

Support

Insulin resistance makes weight management harder by disrupting how the body processes glucose and stores fat.

Berberine, Quercetin, and Myricetin support multiple metabolic pathways tied to insulin sensitivity, helping your body use blood sugar more efficiently.*‡

Plant-Powered Ingredients
That Help Contol Hunger

01

Allulose1-2

A rare naturally occurring sugar with near-zero calories. Studies show it supports GLP-1 secretion and helps moderate post-meal glucose response.*‡

02

Inulin3-4

A prebiotic fiber from chicory root shown to support GLP-1 release via gut microbiota signaling, improving appetite regulation and glucose tolerance.*‡

03

Berberine5-7

One of the most studied plant compounds in metabolic science. Research shows it supports natural GLP-1 secretion, inhibits the DPP-4 enzyme, and improves insulin sensitivity-the cornerstone ingredient in the formula.*‡

04

Mulberry Leaf Extract8-9

Studied for supporting balanced post-meal blood sugar and acting as a natural DPP-4 inhibitor, helping preserve active GLP-1 levels.*‡

05

Myricetin10-11

A flavonoid shown to support GLP-1 secretion, healthy glucose metabolism, and cellular insulin signaling.*‡

06

Quercetin12-13

A widely studied flavonoid with documented DPP-4 inhibitory activity, supporting healthy glucose uptake and reduced inflammation tied to insulin resistance.*‡

References

1. Iida T, et al. D-Allulose Ingestion Stimulates GLP-1 Secretion in Healthy Adults. J Nutr Sci Vitaminol. 2017;63(5):291-297.

2. Han Y, et al. Allulose supplementation reduces BMI and abdominal fat. Nutrients. 2018;10(2):160.

3. Delannoy-Bruno O, et al. Evaluating microbiome-directed fibre snacks in mice and humans. Nature. 2021;595(7865):91-95.

4. Cani PD, et al. Gut microbiota fermentation of prebiotics increases incretin gut peptide production. Am J Clin Nutr. 2009;90(5):1236-1243.

5. Yin J, et al. Efficacy of Berberine in Patients with Type 2 Diabetes Mellitus. Metabolism. 2008;57(5):712-717.

6. Zhang H, et al. Berberine lowers blood glucose through increasing insulin receptor expression. Metabolism. 2010;59(2):285-292.

7. Cao C, et al. Berberine inhibits DPP-4 activity and improves GLP-1 levels. Journal of Diabetes. 2019;11(3):228-236.

8. Chen F, et al. Mulberry leaf polyphenols inhibit DPP-4 and alpha-glucosidase. Food Chemistry. 2015;168:62-68.

9. Naowaboot J, et al. Mulberry leaf extract effects in streptozotocin-induced diabetic rats. Nutrition Research. 2009;29(8):602-608.

10. Liu IM, et al. Myricetin ameliorates insulin resistance in rats. Life Sciences. 2007;81(21-22):1479-1488.

11. Baranowska-Wojcik E, et al. Myricetin — GLP-1 secretion and metabolic effects. Phytomedicine. 2020;78:153294.

12. Shi Y, et al. Quercetin inhibits DPP-4 activity and enhances GLP-1 levels in obese rats. Phytomedicine. 2019;57:51-58.

13. Eid HM, et al. Quercetin induces differentiation of pancreatic beta cells. Molecules. 2017;22(10):1645.